2-Bromo-5-(trifluoromethyl)benzyl alcohol → (2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

HRID 563495

Reaction equation

HRID 563495 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[CH2:12][OH:13].[CH3:14][O:15][C:16](=[O:35])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20](B2OC(C)(C)C(C)(C)O2)[CH:19]=1>>[CH3:14][O:15][C:16](=[O:35])[CH2:17][C:18]1[CH:19]=[C:20]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=2[CH2:12][OH:13])[C:21]([O:24][CH3:25])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 27562482-Bromo-5-(trifluoromethyl)benzyl alcoholHCID 57576289Methyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetate

Product 1

HCID 66606415(2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (2-bromo-5-trifluoromethyl-phenyl)-methanol and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f10b5cadc393441e9d4eb1c3c8a559bb
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Linked notes

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