2-Bromo-5-nitrobenzoic acid → (2-Bromo-5-nitrophenyl)methanol

HRID 563537

Reaction equation

HRID 563537 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].O1CCCC1.B>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[CH2:4][OH:5]

Participants

3

Reactant 2

HCID 2430252-Bromo-5-nitrobenzoic acidHCID 2723981Borane;tetrahydrofuran

Product 1

HCID 18671373(2-Bromo-5-nitrophenyl)methanol

Procedure

To 2-bromo-5-nitrobenzoic acid (5 g, 20 mmol) at 0° C. was added borane tetrahydrofuran complex (1 M in THF; 200 mL, 200 mmol), and the reaction was stirred at room temperature overnight. The mixture was quenched with 1N aqueous HCl to give the title compound.

Workup

  1. customThe mixture was quenched with 1N aqueous HCl

Sources & evidence

ORD record
ord-10610fa9968e4d3ba8c45c75675bc868
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Linked notes

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