(4-Chlorophenyl)methyl chloroformate → (2'-{[(4-Chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-5'-methyl-biphenyl-3-yl)-acetic acid ethyl ester

HRID 563745

Reaction equation

HRID 563745 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=2[CH2:21][NH:22][CH2:23][CH3:24])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].Cl[C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1)=[O:28]>>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=2[CH2:21][N:22]([C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)=[O:28])[CH2:23][CH3:24])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 13292914(4-Chlorophenyl)methyl chloroformateHCID 58149093(2'-Ethylaminomethyl-6-methoxy-5'-methyl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 58149220(2'-{[(4-Chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-5'-methyl-biphenyl-3-yl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6-methoxy-5′-methyl-biphenyl-3-yl)-acetic acid ethyl ester and 4-chlorobenzyl chloroformate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a47813050f344fc5a65383312e71dd1a
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Linked notes

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