5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol

HRID 563785

Reaction equation

HRID 563785 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH2:7][OH:8])[CH:9]=1

Participants

4

Reactant 2

HCID 7363275-Bromo-2-fluorobenzaldehydeHCID 4311764Sodium borohydride

Product 1

HCID 2773352(5-Bromo-2-fluorophenyl)methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-bromo-2-fluorobenzaldehyde (1.3 g, 6.4 mmol) in MeOH (10 mL) was added sodium borohydride (0.29 g, 7.7 mmol), and the reaction was stirred at room temperature for 5 minutes. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.

Workup

  1. customAfter aqueous work-up, the residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-e013470df19541eaa101c5ba8cb8d399
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Linked notes

Loading…