HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → (-)-2-(3-Pyridinylmethylthio)methyl-5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | (-)-S-[(5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridin-2-yl)methyl]isothiourea | HCID 19796447 | — |
| Reactant | 3-Chloromethylpyridinium hydrochloride | HCID 21477773 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | (-)-2-(3-Pyridinylmethylthio)methyl-5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine | HCID 67863868 | — |
Reaction Steps
A mixture of (-)-S-[(5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridin-2-yl)methyl]isothiourea (mg 500), 3-chloromethylpyridinium hydrochloride (mg 190), benzylthriethylammonium chloride (BTEAC mg 80), KOH (4M, ml 2) and benzene (ml 5) is stirred at room temperature for 15 minutes to separate a precipitate that is filtered and triturated with diethyl ether to give mg 450 of (-)-2-(3-pyridinylmethylthio)methyl-5-cyano-3-carboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05245039 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-88228e4040e04ab3b2c5db9f2b2006b0 |
| Source note | uspto-grants-1993_09 |