4-Methoxybenzenethiol → 2-(4-Methoxy-phenylsulfanyl)pentanoic acid ethyl ester

HRID 565294

Reaction equation

Br[CH:2]([CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([SH:19])=[CH:15][CH:14]=1>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([S:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=1)[CH2:8][CH2:9][CH3:10])[CH3:7]

Participants

Reactant 2

HCID 127654-Methoxybenzenethiol

HCID 79071Ethyl 2-bromovalerate

Product 1

HCID 545709022-(4-Methoxy-phenylsulfanyl)pentanoic acid ethyl ester

Procedure

2-(4-Methoxy-phenylsulfanyl)-pentanoic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from ethyl 2-bromovalerate (8.23 g, 39.3 mmol) and 4-methoxythiophenol (5 g, 35.7 mmol), 10.46 g (100%); clear oil; MS: 269 (M+H)+.

Sources & evidence

ORD record: ord-241ae9ef682c4f76ab61d8292df85fdc
Source dataset: uspto-grants-2001_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06172057B2

Linked notes

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