Benzhydrol → 4-(2-(Diphenylmethoxy)ethyl]piperidine
Reaction equation
[CH:1]([OH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:15]1[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22]O)[CH2:17][CH2:16]1>>[C:2]1([CH:1]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[O:14][CH2:22][CH2:21][CH:18]2[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Procedure
Using benzhydrol and 4-piperidineethanol, the procedure of Reference Example 23 was otherwise repeated to provide the title compound. Yield 94%.
Sources & evidence
- ORD record
- ord-29aa616ba48740e3897a64338dbcd440
- Source dataset
- uspto-grants-2001_01
- Patent number
- US06172085B2
Reaction notes
Loading…