2-Methoxybenzoic acid → 2,3-Dihydro-2-[[4-(2-methoxybenzoyl)-1-piperazinyl]methyl]-2,4,6,7-tetramethyl-5-benzofuranamine
Reaction equation
[CH3:1][C:2]1([CH2:15][N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH2:6][C:5]2[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1.[C:22](O)(=[O:31])[C:23]1[C:24]([O:29][CH3:30])=[CH:25][CH:26]=[CH:27][CH:28]=1>>[CH3:30][O:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:22]([N:19]1[CH2:20][CH2:21][N:16]([CH2:15][C:2]2([CH3:1])[CH2:6][C:5]3[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=3[O:3]2)[CH2:17][CH2:18]1)=[O:31]Participants
3
Procedure
Using 2,3-dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine and o-anisic acid, the procedure of Example 10, presented hereinafter, was otherwise followed to provide the title compound. Yield 42%.
Sources & evidence
- ORD record
- ord-faf0b66e6e694530ad84da4c176375c8