2,3-Dihydroxybutanedioic Acid → HCID 86756217, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=1.[C:16]([OH:25])(=[O:24])[CH:17]([CH:19]([C:21]([OH:23])=[O:22])[OH:20])[OH:18]>O>[C:21]([CH:19]([CH:17]([C:16]([OH:25])=[O:24])[OH:18])[OH:20])([OH:23])=[O:22].[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
(3-Chlorophenyl)phenylmethylamine (9.42g, 43.3 mmol) and (+)-tartaric acid (6.50g, 43.3 mmol) were dissolved in water (40 ml) with heating. Thereafter, the precipitated crude crystals obtained by allowing to cool the reaction solution to room temperature were collected by filtration. The resulting crystals were purified by repeatedly recrystallizing from water, to give (+)-(3-chlorophenyl)phenylmethylamine (+)-tartrate (4.28 g). In order to determine the optical purity of (+)-(3-chlorophenyl)phenylmethylamine (+)-tartrate, HPLC analysis was carried out. Its analytical conditions are as follows.