Tetrahydrophthalic anhydride → HCID 21266144, compound

HRID 566418

Reaction equation

HRID 566418 reaction equation
[CH2:1]([NH2:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[C:20]1(=O)[CH:28]2[CH:23]([CH2:24][CH:25]=[CH:26][CH2:27]2)[C:22](=[O:29])[O:21]1>>[CH2:1]([N:19]1[C:20](=[O:21])[CH:28]2[CH:23]([CH2:24][CH:25]=[CH:26][CH2:27]2)[C:22]1=[O:29])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 6810Tetrahydrophthalic anhydrideHCID 15793Octadecylamine

Product 1

HCID 21266144HCID 21266144, compoundYield 98.7%

Conditions

Temperature
110 °C

Procedure

Octadecylamine (5.31 g) was added to 4,7,3a,7a-tetrahydroisobenzofuran-1,3-dione (3.00 g). After being stirred for 2 hours at 110° C., the reaction mixture was purified by silica gel column chromatography (silica gel 80 g, chloroform), thereby yielding the entitled compound (7.85 g) as yellow crystals.

Workup

  1. customthe reaction mixture was purified by silica gel column chromatography (silica gel 80 g, chloroform)

Sources & evidence

ORD record
ord-ad23ef1d4f0946fd99ee776370455660
Source dataset
uspto-grants-2001_01
Patent number
US06174885B1

Linked notes

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