HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl bromoacetate → tert-Butyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Product | tert-Butyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate | HCID 117622649 | — |
Reaction Steps
4.9 g (28.4 mmol) of 4-bromopyridin-2(1H)-one and 1.2 eq. of tert-butyl 2-bromoacetate were reacted according to General Method 4B at 120° C. After aqueous work-up, the crude product was reacted further without further purification. Yield: 8.6 g (purity 91%, 95% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-0ebd5d658add447c96942101750407a7 |
| Source note | uspto-grants-2016_09 |