HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Chloro-2-methoxypyridin-4-yl)boronic acid | HCID 11030558 | — |
| Reactant | 2-Bromo-4-chloro-1-(difluoromethyl)benzene | HCID 66744942 | — |
| Product | 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine | HCID 117604825 | — |
Reaction Steps
463 mg (purity 93%, 2.3 mmol) of (5-chloro-2-methoxypyridin-4-yl)boronic acid and 515 mg (2.1 mmol) of 2-bromo-4-chloro-1-(difluoromethyl)benzene in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 305 mg (purity 77%, 34% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-9f8edd3dd2a2499d8bb12cfe532680b7 |
| Source note | uspto-grants-2016_09 |