2-Bromopropionic acid → 2-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid

HRID 56707

Reaction equation

HRID 56707 reaction equation
[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH:16]([F:18])[F:17])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH:20]([CH3:24])[C:21]([OH:23])=[O:22]>>[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH:16]([F:18])[F:17])=[CH:4][C:5](=[O:8])[N:6]([CH:20]([CH3:24])[C:21]([OH:23])=[O:22])[CH:7]=1

Participants

3

Reactant 2

HCID 117292-Bromopropionic acidHCID 1176055865-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one

Product 1

HCID 1176228992-{5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid

Procedure

118 mg (0.41 mmol) of 5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]pyridin-2(1H)-one and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 35° C. Yield: 112 mg (76% of theory)

Workup

  1. customaccording to General Method 4A at 35° C

Sources & evidence

ORD record
ord-f46809968d4f4934871de5b1cc97ab55
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Linked notes

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