2-Bromo-4-chlorobenzonitrile → 4-(5-Chloro-2-cyanophenyl)-6-methoxypyridin-3-carbonitrile
Reaction equation
[C:1]([C:3]1[C:4](B(O)O)=[CH:5][C:6]([O:9][CH3:10])=[N:7][CH:8]=1)#[N:2].Br[C:15]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:16]=1[C:17]#[N:18]>>[Cl:23][C:21]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[C:15]([C:4]2[CH:5]=[C:6]([O:9][CH3:10])[N:7]=[CH:8][C:3]=2[C:1]#[N:2])[CH:22]=1Participants
3
Procedure
600 mg (purity 89%, 3.0 mmol) of 5-cyano-2-methoxypyridin-4-ylboronic acid and 649 mg (3.0 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. After aqueous work-up, the crude product was triturated with water and then with cyclohexane/ethyl acetate (7:3), and the solid was filtered off and dried under high vacuum. Yield: 399 mg (purity 94%, 46% of theory)
Workup
- customAfter aqueous work-up, the crude product was triturated with water
- filtration