HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-chlorobenzonitrile → 4-Chloro-2-[2-methoxy-5-(trifluoromethyl)pyridin-4-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-chlorobenzonitrile | HCID 23498524 | — |
| Reactant | 2-Methoxy-5-(trifluoromethyl)pyridine-4-boronic acid | HCID 118704437 | — |
| Product | 4-Chloro-2-[2-methoxy-5-(trifluoromethyl)pyridin-4-yl]benzonitrile | HCID 117605758 | — |
Reaction Steps
1.0 g (4.4 mmol) of 2-methoxy-5-trifluoromethylpyridin-4-ylboronic acid and 0.95 g (4.4 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 351 mg (purity 71%, 18% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1fa0044468674d8d8fcdb79c4ca3d961 |
| Source note | uspto-grants-2016_09 |