Pyridinium hydrochloride → 4-Chloro-2-(5-methoxy-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

HRID 56736

Reaction equation

HRID 56736 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][N:13]=[C:12]([O:18]C)[CH:11]=2)[CH:3]=1.Cl.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([O:16][CH3:17])=[CH:14][NH:13][C:12](=[O:18])[CH:11]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 21584435Pyridinium hydrochlorideHCID 1176052164-Chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile

Product 1

HCID 1176049354-Chloro-2-(5-methoxy-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

Procedure

7.23 g (purity 92%, 24.21 mmol) of 4-chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile and pyridinium hydrochloride were reacted according to General Method 3A. Yield: 6.66 g (purity 91%, 96% of theory)

Sources & evidence

ORD record
ord-98ee7d7df32b4f6189a8ec6c730c6824
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Linked notes

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