Hydrazine → 4-(4-Fluorophenyl)-1,2-dihydrophthalazin-1-one

HRID 567712

Reaction equation

HRID 567712 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.[NH2:19][NH2:20]>C(O)C>[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]2[C:8]3[C:9](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:10](=[O:11])[NH:20][N:19]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 820992-(4-Fluorobenzoyl)benzoic acid

Product 1

HCID 7222584-(4-Fluorophenyl)-1,2-dihydrophthalazin-1-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-fluorobenzoyl)benzoic acid (5 g; 20.47 mmol) is suspended in ethanol (100 ml). Hydrazine (3 M in ethanol; 60 mmol) is added, and the mixture is stirred at room temperature for 4 days. A white solid precipitates, is filtered off and is washed with ethanol (20 ml). Yield: 3.20 g of 4-fluorophenylphthalazine-1-one.

Workup

  1. customA white solid precipitates
  2. filtrationis filtered off
  3. washis washed with ethanol (20 ml)

Sources & evidence

ORD record
ord-81964d5302624df294132cb605225853
Source dataset
uspto-grants-2001_01
Patent number
US06180629B2

Linked notes

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