2-Bromophenyl isocyanate → (2-Bromophenyl)urea
Reaction equation
OC1C=C(C=CC=1[NH2:11])C(O)=O.[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]=[C:20]=[O:21]>>[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][C:20](=[O:21])[NH2:11]Participants
3
Procedure
The urea was prepared from 3-hydroxy 4-amino benzoic acid (3.69 g, 24 mmol) and 2-bromophenylisocyanate(24 mmol) by general Method B. It was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane(4.0 g, 48%). EI-MS m/z 351(M+H)+.
Workup
- customIt was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane(4.0 g, 48%)
Sources & evidence
- ORD record
- ord-fc0d67d4d84e43fba03b9889028ed2b0
- Source dataset
- uspto-grants-2001_01
- Patent number
- US06180675B2
Reaction notes
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