Ammonia → 3-Amino-4-[7-pyrrolidinohept-5-ynylamino]-1,2,5-thiadiazole-1-oxide

Reaction equation

[N:1]1([CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])[CH2:5][CH2:4][CH2:3][CH2:2]1.CO[C:16]1[C:20](OC)=[N:19][S:18](=[O:23])[N:17]=1.[NH3:24]>>[NH2:24][C:16]1[C:20]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]#[C:7][CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:19][S:18](=[O:23])[N:17]=1

Participants

Reactant 3

HCID 222Ammonia

HCID 129139473,4-Dimethoxy-1,2,5-thiadiazole 1-oxide

HCID 201476447-Pyrrolidinohept-5-ynylamine

Product 1

HCID 201476613-Amino-4-[7-pyrrolidinohept-5-ynylamino]-1,2,5-thiadiazole-1-oxide

Procedure

In a manner similar to Example 1, reaction of 7-pyrrolidinohept-5-ynylamine and 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide followed by treatment with ammonia gives the title compound.

Sources & evidence

ORD record: ord-0174f53e131843cbad8d5389a6ba606a
Source dataset: uspto-grants-1988_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04732980

Reaction notes

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