Tetraethyl (1-phenoxypropylidene)-bisphosphonate → (1-Phenoxypropylidene)-bisphosphonic acid
Reaction equation
[O:1]([C:8]([P:19](=[O:26])([O:23]CC)[O:20]CC)([P:11](=[O:18])([O:15]CC)[O:12]CC)[CH2:9][CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C[Si](C)(C)Br>[O:1]([C:8]([P:19](=[O:20])([OH:23])[OH:26])([P:11](=[O:12])([OH:15])[OH:18])[CH2:9][CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of tetraethyl (1-phenoxypropylidene)-bisphosphonate (2.1 g) in trimethyl bromosilane (8 ml) was kept at room temperature overnight, followed by evaporation in vacuo. The residue was stirred overnight in absolute ethanol. Evaporation in vacuo gave the desired compound.
Workup
- customfollowed by evaporation in vacuo
- customEvaporation in vacuo
Sources & evidence
- ORD record
- ord-ce4bfa27ba54486e83aac61cf44faeef
- Source dataset
- uspto-grants-1988_03
- Patent number
- US04732998
Reaction notes
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