HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminum hydride → (1H-indol-5-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (1H-indol-5-yl)methanol | HCID 2773458 | — |
Reaction Steps
96 g (0.548 mole) of 6b are treated analogously to Example 1a in 1,800 ml of ether and 1,391 ml (1.67 moles) of DIBAL (1.2 molar in toluene). After chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product are obtained. C9H9NO (147.2)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04734407 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-bc1b83dde3684cc4aa27d378a6abf204 |
| Source note | uspto-grants-1988_03 |