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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 569813Generated: October 23, 2026

1,4-Dioxane → 7-Bromo-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline

https://huagongshe.com/en/reaction/569813

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DioxaneHCID 31275—
Reactant2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamideHCID 14458995—
Product7-Bromo-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazolineHCID 14459003—

Reaction Conditions

Temperature150 °C

Reaction Steps

2-Amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (2.90 g) and N,N'-carbonyldiimidazole (4.68 g) were dissolved in dioxane (50 ml). The solution was evaporated to give a residue, which was stirred at 150° C. for 30 minutes. After cooling, the precipitates were collected by filtration and washed with ethanol to give 7-bromo-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazoline (2.92 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04734419
Source datasetuspto-grants-1988_03
ORD IDord-972835d6878a434e94518b5c14195c7f
Source noteuspto-grants-1988_03