Hydrazine → HCID 178434195, compound

HRID 569892Notes

Reaction equation

HRID 569892 reaction equation
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][CH2:7][CH2:6][C:5]1=O)(=O)[CH3:2].[NH2:12][NH2:13]>CO>[CH3:2][C:1]1[C:4]2[C:9](=[O:10])[CH2:8][CH2:7][CH2:6][C:5]=2[NH:13][N:12]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 1381042-Acetyl-1,3-cyclohexanedione

Product 1

HCID 178434195HCID 178434195, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To an ice-cold solution of 33.3 grams of 2-acetyl1,3-cyclohexanedione in 400 ml of methanol was added dropwise a solution of 7.2 ml of hydrazine in 50 ml of methanol and the resulting reaction mixture was heated at reflux for 20 hours. The solvent was then removed under reduced pressure and the residue was triturated in ethyl ether to give 1,5,6,7-tetrahydro-3-methyl-4H-indazol-4-one as a yellow crystalline solid melting at about 154°-157° C.

Workup

  1. customthe resulting reaction mixture
  2. temperaturewas heated
  3. temperatureat reflux for 20 hours
  4. customThe solvent was then removed under reduced pressure
  5. customthe residue was triturated in ethyl ether

Sources & evidence

ORD record
ord-ae23a9e5c6a941738e1d4046f760fa91
Source dataset
uspto-grants-1988_03
Patent number
US04734429

Reaction notes

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