Thionyl Chloride → 3,5-Difluoropyridine-2-carbonyl chloride
Reaction equation
[F:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([C:9]([Cl:14])=[O:11])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1Participants
3
Procedure
A suspension of 5.00 g (31.4 mmol) of 3,5-difluoropyridine-2-carboxylic acid in thionyl chloride (21 ml) was heated to reflux for 5 h. The solution was concentrated, and the residue was twice taken up in a little toluene and concentrated again. This gave 3.80 g of a solid, which was converted further directly without further purification.
Workup
- temperaturewas heated
- temperatureto reflux for 5 h
- concentrationThe solution was concentrated
- concentrationconcentrated again
- customThis gave 3.80 g of a solid, which was converted further directly without further purification
Sources & evidence
- ORD record
- ord-b14b5d4b849e4272903e530b7f329717
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09023849B2
Reaction notes
Loading…