[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][CH3:10])[N:5]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[CH:13][CH:12]=2)[C:4](=[O:23])[CH:3]=1.C([O-])(=O)C.[Na+].[Br:29]Br.O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH2:9][CH3:10])[N:5]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][C:19]([F:21])([F:22])[F:20])=[CH:15][CH:16]=2)[C:4](=[O:23])[C:3]=1[Br:29]To a solution of 6-amino-2-(ethylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrimidin-4(3H)-one (0.5 g) and sodium acetate (0.143 g) in acetic acid (10 mL) was added dropwise bromine (0.09 mL), and the mixture was stirred at room temperature for 2 hr. To the reaction mixture was added water, and the precipitated crystals were collected by filtration to give the title compound (0.1 g).
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