Sodium Methoxide → HCID 86697864, compound
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[S:15][C:16](Br)=[N:17][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:19][O-:20].[Na+]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[S:15][C:16]([O:20][CH3:19])=[N:17][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.00 g (3.00 mmol) bromo-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepine-6-carboxylic acid tert-butyl ester, 0.40 g (7.00 mmol) sodium methylate in 15 mL methanol were heated at 100° C. for 4 h under microwave irradiation. The mixture was purified by chromatography.
Workup
- customThe mixture was purified by chromatography
Sources & evidence
- ORD record
- ord-e0578dacedec4d328ea8746c99d34f47
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09029360B2
Reaction notes
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