HCID 13764015, compound → HCID 13764016, compound
Reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[C:6]([C:10]3[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=3)[C:5]=12>[Pd].CO>[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][CH:6]([C:10]3[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=3)[C:5]=12Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 4-(imidazo[1,2-a]pyridin-8-yl)phenol (0.22 g), 10% palladium on carbon (containing water (50%), 0.10 g) and methanol (15 ml) was stirred under a hydrogen atmosphere at room temperature for 5 days. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The obtained solid was washed with ethyl acetate to give the title compound (0.14 g).
Workup
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
- washThe obtained solid was washed with ethyl acetate
Sources & evidence
- ORD record
- ord-6c8cd041733045f4a51bcd6e63d96df1
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09029388B2
Reaction notes
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