2-methyl-1H-indol-5-ol → 2-(2-Amino-pyridin-4-yloxy)-4-fluoro-benzoic acid methyl ester

HRID 573104

Reaction equation

HRID 573104 reaction equation
F[C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7]C)=[O:5].[NH2:14][C:15]1[CH:20]=[C:19]([OH:21])[CH:18]=[CH:17][N:16]=1.CC1NC2C(C=1)=CC(O)=CC=2>>[CH3:7][O:6][C:4](=[O:5])[C:3]1[CH:9]=[CH:10][C:11]([F:13])=[CH:12][C:2]=1[O:21][C:19]1[CH:18]=[CH:17][N:16]=[C:15]([NH2:14])[CH:20]=1

Participants

4

Reactant 3

HCID 833362-methyl-1H-indol-5-olHCID 2737170Benzoic acid, 2,4-difluoro-, ethyl esterHCID 178507942HCID 178507942, compound

Product 1

HCID 672278842-(2-Amino-pyridin-4-yloxy)-4-fluoro-benzoic acid methyl ester

Procedure

The title compound was prepared by substituting methyl 2,4-difluorobenzoate for ethyl 2,4-difluorobenzoate and 2-aminopyridin-4-ol for 2-methyl-5-indolol in EXAMPLE 3A, except here heating was at 130° C.

Workup

  1. temperatureexcept here heating
  2. customwas at 130° C.

Sources & evidence

ORD record
ord-3b599d003da043559b397b090ff61417
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Linked notes

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