2-Iodobenzylic alcohol → 2-Iodobenzaldehyde

HRID 573469

Reaction equation

HRID 573469 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>ClCCl.[O-2].[Mn+2]>[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 1

HCID 1076292-Iodobenzylic alcohol

Product 1

HCID 6434392-IodobenzaldehydeYield 91%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 6344DichloromethaneSolvent

Procedure

In a flask, 2-iodobenzyl alcohol (4 g, 17.09 mmol) was dissolved in dichloromethane (MC, 85 ml), and then, manganese oxide (MnO2, 14.86 g, 170.92 mmol) was added thereto. The obtained reaction product was stirred under the reflux condition. When the reaction was completed, the obtained reaction product was cooled to the room temperature, and then, fiteated and concentrated using celite, to obtain the title compound (3.6 g, yield 91%).

Workup

  1. customThe obtained reaction product
  2. customthe obtained reaction product
  3. concentrationfiteated and concentrated

Sources & evidence

ORD record
ord-4e7787d867b241b6965a32d5b6f0e10d
Source dataset
uspto-grants-2015_05
Patent number
US09029589B2

Linked notes

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