Dimethyl Sulfate → 1,2,3-Trifluoro-5-methoxy-4-nitrobenzene

Reaction equation

[F:1][C:2]1[C:3]([N+:11]([O-:13])=[O:12])=[C:4]([OH:10])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].S(OC)(O[CH3:18])(=O)=O>>[CH3:18][O:10][C:4]1[CH:5]=[C:6]([F:9])[C:7]([F:8])=[C:2]([F:1])[C:3]=1[N+:11]([O-:13])=[O:12]

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 538809903,4,5-Trifluoro-2-nitrophenol

Product 1

HCID 265968691,2,3-Trifluoro-5-methoxy-4-nitrobenzene

Procedure

Staring from 3,4,5-trifluoro-2-nitrophenol and dimethyl sulfate in place of allyl bromide and using a procedure analogous to that used to prepare Intermediate 6,3,4,5-trifluoro-2-nitro-phenyl methyl ether was prepared.

Workup

customwas prepared

Sources & evidence

ORD record: ord-5017ef80f8174dbab71a1cf7b26849c6
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09034861B2

Reaction notes

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