HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 1-({[(tert-butoxycarbonyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate | HCID 66801809 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride | HCID 89780476 | — |
Reaction Steps
262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034855B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-63ef24af7ed74888b706354e023f6057 |
| Source note | uspto-grants-2015_05 |