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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 574151Generated: October 26, 2026

Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride

https://huagongshe.com/reaction/574151

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantEthyl 1-({[(tert-butoxycarbonyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylateHCID 66801809—
SolventDichloromethaneHCID 6344—
Solvent1,4-DioxaneHCID 31275—
ProductEthyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochlorideHCID 89780476—

Reaction Steps

262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09034855B2
Source datasetuspto-grants-2015_05
ORD IDord-63ef24af7ed74888b706354e023f6057
Source noteuspto-grants-2015_05