Water → 6-(Pyridin-2-yl)pyridazine-3-thiol

HRID 574183

Reaction equation

HRID 574183 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=O)[NH:11][N:12]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:15].O>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=[S:15])[NH:11][N:12]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 49800226-(Pyridin-2-yl)pyridazin-3-ol

Product 1

HCID 49800236-(Pyridin-2-yl)pyridazine-3-thiolYield 92%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

500 mg (2.9 mmol) of pyridazinone 7 and 772 mg (3.5 mmol) of phosphorus pentasulfide are dissolved in 20 ml of anhydrous pyridine. The reaction mixture is brought to reflux for 18 h, and then cooled to ambient temperature. It is then poured into 200 ml of water, and the precipitate thus formed is filtered off and then washed with ice-cold water. The pyridazinethione 10 is obtained with a yield of 92%.

Workup

  1. temperatureto reflux for 18 h
  2. customthe precipitate thus formed
  3. filtrationis filtered off
  4. washwashed with ice-cold water

Sources & evidence

ORD record
ord-ee53a89773d24a1ea64a87dac1a80651
Source dataset
uspto-grants-2015_05
Patent number
US09034873B2

Linked notes

Loading…