Iodide Ion → L-Tyrosine

Reaction equation

[I-].I[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][C:14]=1[OH:15])[CH2:6][C@@H:7]([C:9]([OH:11])=[O:10])[NH2:8]>>[NH2:8][C@H:7]([C:9]([OH:11])=[O:10])[CH2:6][C:5]1[CH:4]=[CH:3][C:14]([OH:15])=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 30165Iodide Ion2×

HCID 4397443-Iodo-L-Tyrosine

Product 1

HCID 6057L-Tyrosine

Procedure

Electrolysis was carried out using the same cell, anode, membrane and procedure as in Example 15, except that the pH of the anolyte and catholyte was 7.0. At 85% iodide conversion, the yield of 3-iodo-L-tyrosine was 58% based on initial iodide.

Sources & evidence

ORD record: ord-1bf8d60c367e45b9942d7471cdaae72c
Source dataset: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05246561

Reaction notes

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