1H-Imidazole-1-propanamine → 3-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]benzo-thieno[2,3-d]pyrimidin-4(1H)-one

HRID 574726

Reaction equation

HRID 574726 reaction equation
[N:1]([C:4]1[S:8][C:7]2[CH2:9][CH2:10][CH2:11][CH2:12][C:6]=2[C:5]=1[C:13]([O:15]CC)=O)=[C:2]=[S:3].[N:18]1([CH2:23][CH2:24][CH2:25][NH2:26])[CH:22]=[CH:21][N:20]=[CH:19]1>>[N:18]1([CH2:23][CH2:24][CH2:25][N:26]2[C:13](=[O:15])[C:5]3[C:6]4[CH2:12][CH2:11][CH2:10][CH2:9][C:7]=4[S:8][C:4]=3[NH:1][C:2]2=[S:3])[CH:22]=[CH:21][N:20]=[CH:19]1

Participants

3

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 2779675Ethyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Product 1

HCID 251005213-[3-(1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]benzo-thieno[2,3-d]pyrimidin-4(1H)-one

Procedure

The compound was synthesized starting from ethyl 4,5,6,7-tetrahydro-2-isothiocyanatobenzo[b]thiophene-3-carboxylate (1.09 g, 4.0 mmol) and 3-(1H-imidazol-1-yl)propan-1-amine (0.5 g, 4.0 mmol) as described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-3776702238ec401eb61adbf1ef9361a0
Source dataset
uspto-grants-2015_05
Patent number
US09034907B2

Linked notes

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