Ammonia → Morpholine-4-carboxamide

HRID 574961Notes

Reaction equation

HRID 574961 reaction equation
[N:1]1([C:7](Cl)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH3:10]>CO>[N:1]1([C:7]([NH2:10])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 848104-Morpholinecarbonyl chloride

Product 1

HCID 75088Morpholine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of morpholine-4-carbonyl chloride (2.0 g) in methanol (10 mL) and 7 N NH3 in methanol (5 mL) was stirred at 45° C. overnight. The mixture was concentrated to give a solid, which was dried under vacuum.

Workup

  1. concentrationThe mixture was concentrated
  2. customto give a solid, which
  3. customwas dried under vacuum

Sources & evidence

ORD record
ord-bc64eee410bf4511854d76a992fb5970
Source dataset
uspto-grants-2015_05
Patent number
US09034875B2

Reaction notes

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