Ethanol → 5,7-Dichloropyrido(3,4-b)pyrazine
Reaction equation
[Cl:1][C:2]1[C:7]([NH2:8])=[C:6]([NH2:9])[CH:5]=[C:4]([Cl:10])[N:3]=1.O.[CH2:12](O)[CH3:13]>C(C=O)=O>[Cl:1][C:2]1[C:7]2[C:6](=[N:9][CH:12]=[CH:13][N:8]=2)[CH:5]=[C:4]([Cl:10])[N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of the solution of 2,6-dichloropyridine-3,4-diamine (7.85 g, 0.044 mol) in ethanol and 40% glyoxal solution in water (26 g, 0.178 mol) was refluxed overnight. It was then cooled to ambient temperature, and the precipitates were collected, washed with EtOH, and dried in vacuo to give the title compound (7.32 g, 83% yield).
Workup
- temperaturewas refluxed overnight
- customthe precipitates were collected
- washwashed with EtOH
- customdried in vacuo
Sources & evidence
- ORD record
- ord-b9dfa39a33924e5292e17cc294459ad9
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434726B2
Reaction notes
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