HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57550Generated: October 26, 2026
N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine → N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-2,5-Pyridinediamine
https://huagongshe.com/reaction/57550
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 71113503 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N2-methyl-N2-(tetrahydro-2H-pyran-4-yl)-2,5-Pyridinediamine | HCID 43610738 | — |
Reaction Steps
To a solution of N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine (217 mg, 0.92 mmol) in MeOH (30 mL) was added Pd/C (0.5 g). The mixture was stirred for 3 hours at 20° C. under 1 atm. H2. The reaction was filtered and concentrated to give dark red oil. MS (m/z): 208 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434726B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-3bdf9a7e1e4441f8bbbb21f22db9e522 |
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| Source note | uspto-grants-2016_09 |
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