2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide → 6-((Dibenzylamino)methyl)morpholin-3-one
Reaction equation
Cl[CH2:2][C:3]([NH:5][CH2:6][CH:7]([OH:24])[CH2:8][N:9]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:4].CC([O-])(C)C.[K+]>CC(O)(C)C>[CH2:10]([N:9]([CH2:8][CH:7]1[CH2:6][NH:5][C:3](=[O:4])[CH2:2][O:24]1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-chloro-N-(3-(dibenzylamino)-2-hydroxypropyl)acetamide (1.0 g, 2.49 mmol), t-BuOK (0.39 g, 3.57 mmol) in t-BuOH (30 mL) was stirred at reflux overnight. After concentration, the residue was purified by column chromatography to give product as white solid.