HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57608Generated: October 23, 2026
Cesium carbonate → 4-(4-(5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazin-7-yl)phenyl)morpholine
https://huagongshe.com/en/reaction/57608
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (4-(Morpholin-4-yl)phenyl)boronic acid | HCID 2795359 | — |
| Reactant | 7-chloro-5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazine | HCID 86717381 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(4-(5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazin-7-yl)phenyl)morpholine | HCID 71113794 | — |
Reaction Steps
A mixture of 7-chloro-5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazine (47 mg, 0.17 mmol), 4-morpholinophenylboronic acid (105 mg, 0.51 mmol), and PdCl2(dppf) (10 mg), Cs2CO3 (130 mg, 0.51 mmol) in dioxane (5 mL) was sealed in a microwave reaction cube, stirred at 180° C. for 60 minutes in a microwave reactor, cooled to ambient temperature, concentrated under reduced pressure, and the residue was purified by chromatography to give the title compound. MS (m/z): 403 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434726B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-8d63c4ea98244ab6add05a9264af3efe |
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| Source note | uspto-grants-2016_09 |
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