(4-(Morpholin-4-yl)phenyl)boronic acid → (S)-1-(1-(7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol

HRID 57624

Reaction equation

HRID 57624 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH:14]([C@@H:17]([OH:19])[CH3:18])[CH2:13]2)[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[CH:3]=1.[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][C:29]([C:2]3[N:11]=[C:10]([N:12]4[CH2:16][CH2:15][CH:14]([C@@H:17]([OH:19])[CH3:18])[CH2:13]4)[C:9]4[C:4](=[N:5][CH:6]=[CH:7][N:8]=4)[CH:3]=3)=[CH:28][CH:27]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 2795359(4-(Morpholin-4-yl)phenyl)boronic acidHCID 86717385(S)-1-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol

Product 1

HCID 86717386(S)-1-(1-(7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol

Procedure

The title compound was prepared according to the procedure of Compound 1 (B) using (S)-1-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)ethanol and 4-morpholinophenylboronic acid. MS (m/z): 406 (M+H)+.

Sources & evidence

ORD record
ord-ed0564b52aa7489a890b56a40958687a
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Linked notes

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