HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isothiocyanatoformate → Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isothiocyanatoformate | HCID 85320 | — |
| Reactant | 2-Amino-3-bromopyridine | HCID 817700 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate | HCID 59199107 | 100.1% |
Reaction Steps
To a solution of 2-amino-3-bromopyridine (50.0 g, 289 mmol, 1 equiv) in dichloromethane (500 mL) was added dropwise ethoxycarbonyl isothiocyanate (39.0 g, 297 mmol, 1.03 equiv) at room temperature. After 2 h, dichloromethane was removed in vacuo to provide crude ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate (88 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434732B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3f38827b80af4bdb9a6ae3cdfa4213f7 |
| Source note | uspto-grants-2016_09 |