2,6-Dimethylmorpholine, cis- → 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid

Reaction equation

[Cl:1][C:2]1[C:3](F)=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6].[CH3:13][C@H:14]1[O:19][C@@H:18]([CH3:20])[CH2:17][NH:16][CH2:15]1>>[Cl:1][C:2]1[C:3]([N:16]2[CH2:15][C@H:14]([CH3:13])[O:19][C@H:18]([CH3:20])[CH2:17]2)=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6]

Participants

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-

HCID 27735323-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 673589363-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid

Procedure

Starting materials: 3-chloro-2,4-difluorobenzoic acid and cis-2,6-dimethylmorpholine.

Sources & evidence

ORD record: ord-88d0bda3c0484902b8bb7ea26f8f2695
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040528B2

Reaction notes

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