2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole

HRID 5790

Reaction equation

HRID 5790 reaction equation
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N+:14]([O-])=O)[C:11]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]3)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Ni]>[NH2:14][C:12]1[C:11]([N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)=[CH:10][C:8]2[N:9]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6][C:7]=2[CH:13]=1

Participants

4

Reactant 1

HCID 197942002-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole

Product 1

HCID 197941766-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 86 g of the above nitro compound in 150 ml of ethanol is hydrogenated in presence of 30 g of Raney nickel at 45°. The solution is filtered to give 6-amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole, melting at 130° C.

Workup

  1. filtrationThe solution is filtered

Sources & evidence

ORD record
ord-c4b9469cd7684e858e4abf2ec83970cc
Source dataset
uspto-grants-1993_09
Patent number
US05246927

Linked notes

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