L-Aspartic Acid → HCID 178512698, compound

HRID 579843

Reaction equation

HRID 579843 reaction equation
[CH:1]1[S:5][C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[N:3][C:2]=1[CH2:10][S:11][CH2:12][CH2:13][C:14]([NH:16][S:17]([NH2:20])(=[O:19])=[O:18])=[NH:15].[NH2:21][C@H:22]([C:27]([OH:29])=[O:28])[CH2:23][C:24]([OH:26])=[O:25]>ClCCl>[CH:1]1[S:5][C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[N:3][C:2]=1[CH2:10][S:11][CH2:12][CH2:13][C:14]([NH:16][S:17]([NH2:20])(=[O:19])=[O:18])=[NH:15].[NH2:21][C@H:22]([C:27]([O-:29])=[O:28])[CH2:23][C:24]([O-:26])=[O:25]

Participants

4

Reactant 2

HCID 5960L-Aspartic AcidHCID 178418935HCID 178418935, compound

Product 1

HCID 178512698HCID 178512698, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 0.56 g (0.166 cmole) of famotidine and 0.222 g (0.166 cmole) of aspartic acid was suspended in dichloromethane (10 ml). The mixture was stirred for 3 hours at room temperature, was filtered, washed with dichloromethane and dried. Weight: 0.782 g. Quantitative yield. Stereoscopically homogenous white microcrystalline solid, similar to milky quartz. Slightly bitter taste. M.P.: 165°-170° C. IR FIG. 2.

Workup

  1. filtrationwas filtered
  2. washwashed with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-f1b01b4e29a740aa9b69fbc4007a5bb9
Source dataset
uspto-grants-1988_06
Patent number
US04749790

Linked notes

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