Acetic Anhydride → 4-Acetoxy-alpha-methylcinnamic acid
Reaction equation
[OH:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15].O[ClH](O)(=O)=O>N1C=CC=CC=1>[C:14]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1)(=[O:16])[CH3:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In 100 ml of pyridine was dissolved 18 g of refined 4-hydroxy-α-methylcinnamic acid synthesized in Referential Example 1, 20 g of acetic anhydride was dropped into the solution, and the reaction was carried out at room temperature with stirring for 2 hours. Then, the liquid reaction mixture was dropped in a 1% by weight aqueous solution of hydroxychloric acid, and the precipitated reaction product was recovered by filtration, washed with water, and dried to obtain 20 g of 4-acetoxy-α-methylcinnamic acid.