Ammonia → Perimidine
Reaction equation
[CH:1](O)=O.[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[NH2:15])[CH:8]=[CH:7][CH:6]=1.N>O>[NH:4]1[C:5]2=[C:14]3[C:9](=[CH:8][CH:7]=[CH:6]2)[CH:10]=[CH:11][CH:12]=[C:13]3[N:15]=[CH:1]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
95.0 g of formic acid are added to 15.8 g of 1,8-diaminonaphthalene and the mixture is stirred at reflux temperature (100° C.) for 1 hour. Then 200 ml of water are added, and the mixture is cooled to 15-20° C. and adjusted to a pH of 8.5 by addition of 25% strength by weight ammonia. It is cooled to 10° C. and subsequently stirred at 10° C. for 1 hour. The product which is precipitated is isolated by filtration, washed with water and dried in vacuo at 800 C.
Workup
- temperaturethe mixture is cooled to 15-20° C.
- temperatureIt is cooled to 10° C.
- stirringsubsequently stirred at 10° C. for 1 hour
- customThe product which is precipitated
- customis isolated by filtration
- washwashed with water
- customdried in vacuo at 800 C
Sources & evidence
- ORD record
- ord-9af8614c6287478f9423faeb1aec397e
- Source dataset
- uspto-grants-1999_07
- Patent number
- US05922086
Reaction notes
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