2-Amino-1-butanol, (+)- → 1-[N-[(1S)-1-Ethyl-2-hydroxyethyl]carbamoyl]-4-[1-[3-(isopropylamino)-2-pyridyl] piperazin-4-yl-carbonyl]benzene
Reaction equation
CO[C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:6][CH:5]=1.[NH2:29][C@@H:30]([CH2:33][CH3:34])[CH2:31][OH:32]>>[CH2:33]([C@H:30]([NH:29][C:3]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:13][CH2:14][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:26])[CH3:27])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:16][CH2:17]2)=[O:11])=[CH:6][CH:5]=1)=[O:28])[CH2:31][OH:32])[CH3:34]Participants
3
Procedure
By the same procedure as described in the example 31, synthesis was carried out starting with 4-[1-[3-(isopropylamino)-2-pyridyl]piperazin4-yl-carbonyl]benzoic acid methyl ester and using (S)-(+)-2-amino-1-butanol. Then, the product was recrystallized using acetonitrile and isopropyl ether to give the desired compound.