Isobutylamine → rac-2,4-Dibromo-N-isobutyl-butyramide

Temperature

0 °C

1.52 g (20.8 mmol) Isobutylamine were dissolved in 3 ml of water, and 13 ml dichloromethane were added. The mixture was cooled to 0° C. and vigorously stirred. A solution of 5.0 g (18.9 mmol) of 2,4-dibromobutanoic acid chloride (J. Med. Chem., 1987, 30, 1995) in 3 ml dichloromethane was added within 5 min. Thereafter a solution of 0.83 g (20.8 mmol) NaOH in 1.5 ml water was added a a rate resulting in the temperature remaining between 7 and 10° C. After complete addition, stirring was continued for 3 h at this temperature. Finally the phases were separated and the aqueous phase was extracted thrice with 15 ml dichloromethane. The combined organic phases were washed once with 17 ml 0.5M HCl, once with 14 ml 5% sodium bicarbonate solution and once with 10 ml brine and dried over magnesium sulfate. After evaporation of the solvent a colourless solid was obtained.

1. customresulting in the temperature
2. customremaining between 7 and 10° C
3. additionAfter complete addition
4. stirringstirring
5. customFinally the phases were separated
6. extractionthe aqueous phase was extracted thrice with 15 ml dichloromethane
7. washThe combined organic phases were washed once with 17 ml 0.5M HCl, once with 14 ml 5% sodium bicarbonate solution and once with 10 ml brine
8. dry with materialdried over magnesium sulfate
9. customAfter evaporation of the solvent a colourless solid
10. customwas obtained

ORD record

ord-b0005311c02a46f38121a505e7a22140

Source dataset

uspto-grants-1999_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05925632