Diethyl Ether → (1S)-1-Methyl-2-nitroxyethylamine hydrochloride

HRID 582596

Reaction equation

HRID 582596 reaction equation
C(OC([NH:8][C@@H:9]([CH3:15])[CH2:10][O:11][N+:12]([O-:14])=[O:13])=O)(C)(C)C.CCOCC.[ClH:21].O1CCOCC1>>[ClH:21].[CH3:15][C@H:9]([NH2:8])[CH2:10][O:11][N+:12]([O-:14])=[O:13]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 204431481,4-Dioxane hydrochlorideHCID 45092343(1S)-N-(t-butoxycarbonyl)-1-methyl-2-nitroxyethylamine

Product 1

HCID 86754033(1S)-1-Methyl-2-nitroxyethylamine hydrochloride

Procedure

In 80 ml of 4N hydrochloric acid-dioxane were dissolved 4.52 g of (1S)-N-(t-butoxycarbonyl)-1-methyl-2-nitroxyethylamine, and the mixture was left to stand at room temperature for 1 hour and 50 minutes. To the mixture were added 160 ml of ether, and the crystals were collected by filtration and dried to obtain 3.02 g of the desired compound as colorless crystals.

Workup

  1. waitthe mixture was left
  2. filtrationthe crystals were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-0b5319124384440b89bf08f57523dfd4
Source dataset
uspto-grants-1999_07
Patent number
US05925658

Linked notes

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