N-benzyloxycarbonyl-3-[3-(4-formylpiperazin-1-yl)-propoxy]-4-methoxybenzylamine → 3-(3-(4-Formylpiperazin-1-yl)-propoxy]-4-methoxybenzylamine

HRID 583111

Reaction equation

C(OC([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][N:28]([CH:31]=[O:32])[CH2:27][CH2:26]2)[CH:14]=1)=O)C1C=CC=CC=1>[C].[Pd].C(O)C>[CH:31]([N:28]1[CH2:27][CH2:26][N:25]([CH2:24][CH2:23][CH2:22][O:21][C:15]2[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=2[O:19][CH3:20])[CH2:12][NH2:11])[CH2:30][CH2:29]1)=[O:32]

Participants

Conditions

Temperature: 60 °C

Procedure

A mixture comprising 30.4 g of N-benzyloxycarbonyl-3-[3-(4-formylpiperazin-1-yl)-propoxy]-4-methoxybenzylamine, 3.1 g of 5% palladium carbon and 300 ml of ethanol, was stirred at 60° C. for 9 hours under a hydrogen atmosphere. Palladium carbon was filtered off, and then the filtrate was distilled off under reduced pressure to obtain 17.99 g of the above-identified compound as slightly brown oil.

Workup

filtrationPalladium carbon was filtered off
distillationthe filtrate was distilled off under reduced pressure

Sources & evidence

ORD record: ord-d982800720d6455987588f91bb211934
Source dataset: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05929074

Linked notes

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